Efficacy and Safety of Cefoperazone Sodium-Sulbactam Sodium in the Treatment of Complicated Urinary Tract Infections in Women: A Retrospective Study
Abstract
OBJECTIVE
This study aimed to investigate the clinical efficacy of cefoperazone sulbactam sodium in female patients with complicated urinary tract infection and determine its effect on bacterial clearance and improvement of renal function.
METHODS
A retrospective collection of medical records related to urinary tract infections was conducted for patients admitted between June 2021 and May 2024. The blood routine renal function indexes, the type culture and positive rate of urine bacteria after treatment and the bacterial clearance rate were compared between the two groups before and after treatment. The improvement in clinical symptoms and the incidence of adverse reactions during treatment were observed.
RESULTS
A total of 211 patients with complicated urinary tract infections were screened as study subjects. Among them, 106 patients received cefoperazone/sulbactam, and 105 patients received levofloxacin. Before treatment, the baseline characteristics of the two groups were similar, with consistent bacterial distribution in urine cultures, rendering them comparable (p > 0.05). Both groups of patients received a 7-day treatment course. After treatment, the white blood cell count and renal function indexes of serum creatinine and blood urea nitrogen in the cefoperazone sulbactam group were lower than those in the levofloxacin group (p 0.05).
CONCLUSIONS
Cefoperazone sodium-sulbactam sodium has shown high efficacy in the treatment of complicated urinary infections in…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 211 participants or records.
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