Analysis of Levofloxacin and Comparator Antibiograms against Urinary Tract Infection (UTI) Isolates of E. coli and Other Enterobacteriaceae Across the United States
Abstract
Background: Uncomplicated UTIs (uUTI) are commonly encountered infections particularly among women. The vast majority are caused by E. coli, while other enteric bacilli (K. pneumoniae and Proteus spp.) are also common. Empiric use of trimethoprim-sulfamethoxazole (SXT) to treat uncomplicated UTIs may contribute to increased SXT resistance (R) and multidrug-R (R to ≥2 drugs, AMP-SXT and AMP-SXT-FQ). Fluoroquinolones are often used where SXT-R among uropathogens is high (>20%). To facilitate local management of UTIs, this study examined the regional susceptibility of UTI isolates to common therapeutics including SXT and levofloxacin (LVX). Methods: Analysis was based on regional US data for 2006 from The Surveillance Network (TSN®), which included susceptibility data for LVX, SXT, ciprofloxacin (CIP) and ampicillin (AMP) against outpatient UTI isolates of E. coli and other enterics (K. pneumoniae, P. mirabilis, C. freundii, E. cloacae, and S. marcescens). Results: Overall, E. coli UTI isolates were more susceptible to LVX and CIP (87%), than SXT (79%) and AMP (58%). High level SXT-R (>20%) was observed in 6/9 regions: WN Central 20%, Pacific 22%, Mountain/ES Central/S Atlantic 23%, and WS Central 25%. LVX susceptibility rates remained high among these regions: WN Central/Pacific/Mountain 89%, ES Central 87%, S Atlantic 83%, and WS Central 86%. UTI isolates of other enterics were most susceptible to LVX (89%), CIP (88%), and SXT (87%), and were least susceptible to AMP (29%).…
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.