Randomized controlled study on gatifloxacin and levofloxacin injectionin the treatment of acute gonococcal urinary and reproductive tract infections
Abstract
Objective:To study the efficacy and safety of gatifloxacin injection in the treatment of acute gonococcal urinary and reproductive tract infections.Methods:Taken levofloxacin as control,a double-blinded,randomized-controlled clinical trial was conducted.A total of 38 patients were enrolled (19 in trial group,19 in control group).The regimens were as follows:Either gatifloxacin or levofloxacin 0.2g,iv,twice a day for 7～14 days.Results:The cure rate,effective rate and bacterial clearance rate for trial groups were 100%,and those for control groups were 96.2%,100% and 100%,respectively.The mycoplasma and chlamydia clearance rates for trial groups were 100%,and those for control groups were 85.71% and 100% respectively.Statistic analysis did not show significant differences between the two groups ( P 0.05).No adverse effects were observed in both groups.Conclusion:The efficacy and safety of gatifloxacin are similar to those of levofloxacin in the treatment of acute gonococcal urinary and reproductive tract infections.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 38 participants or records.
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