Low-complexity automated nucleic acid amplification tests for extrapulmonary tuberculosis and rifampicin resistance in adults and adolescents
Abstract
Background: Low-complexity automated nucleic acid amplification tests (LC-aNAATs) are molecular World Health Organization (WHO)-recommended rapid diagnostic tests widely used for simultaneous detection of Mycobacterium tuberculosis complex and rifampicin resistance in sputum. To extend our previous review on extrapulmonary tuberculosis, we performed this update to inform a WHO policy update.
Objectives: To estimate the diagnostic accuracy of LC-aNAATs for extrapulmonary tuberculosis and rifampicin resistance in adults and adolescents with presumptive extrapulmonary tuberculosis.
Search methods: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Science Citation Index, Latin American Caribbean Health Sciences Literature, Scopus, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, the International Standard Randomized Controlled Trial Number Registry, and ProQuest, up to 11 October 2023, without language restriction. A WHO public call for data was made between 30th November 2023 and 15th February 2024 to identify unpublished studies.
Selection criteria: We included cross-sectional and cohort studies using non-respiratory specimens and eight forms of extrapulmonary tuberculosis: tuberculous meningitis and pleural, lymph node, bone or joint, genitourinary, peritoneal, pericardial, and disseminated tuberculosis. Reference standards were culture and a study-defined composite reference standard (tuberculosis detection); and…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 1,397 participants or records.
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