Proliferative glomerulonephritis with monoclonal immunoglobulin IgG1-κ deposition in a patient with type 1 diabetes: a case report and literature review
Abstract
Background: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a rare glomerular disease characterized by edema, proteinuria, and renal insufficiency. No established treatment protocol is currently available. We report a case of PGNMID with monoclonal IgG1-κ deposits in a patient with a 19-year history of type 1 diabetes.
Case presentation: A 30-year-old woman presented with a 1-week history of nausea, vomiting, and generalized edema. She had a 19-year history of type 1 diabetes mellitus with poor glycemic control. Three months before admission, she had been hospitalized for fever and was diagnosed with a urinary tract infection, during which her renal function was normal. After discharge, she continued to experience recurrent episodes of fever. One week before admission, she gradually developed generalized edema accompanied by decreased urine output. On admission, she was found to have nephrotic-range proteinuria, hypoalbuminemia, anemia, acute renal failure, and acute heart failure. After antimicrobial therapy, renal replacement therapy, and nutritional support, the patient underwent renal biopsy. Immunofluorescence showed diffuse, global, granular, and lumpy deposits of IgG, C3, and κ light chain along the glomerular capillary loops and in the mesangial regions, with strong IgG1 positivity. Electron microscopy revealed proliferation of glomerular capillary endothelial cells, accompanied by segmental mesangial matrix interposition into the…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.