Antibiotic Sensitivity Pattern in Escherichia coli Causing Urinary Tract Infection among Inpatients at a Tertiary Care Hospital
Abstract
Urinary tract infections (UTIs) remain the common infections in outpatients as well as hospitalized patients. Recent studies suggest an increasing antimicrobial resistance among Escherichia coli causing urinary tract infection (UTI). Current knowledge on antimicrobial sensitivity pattern is essential for appropriate therapy. The aim of the study is to determine the changing pattern of antibiotic sensitivity in E.coli causing UTI. Bacterial isolates are identified from symptomatic UTI cases attending in hospital were processed for culture and antimicrobial drug susceptibility in the Microbiology lab by Kirby Bauer’s disc diffusion method. Of the total 250 samples, 191 (76.4%) cases were culture-positive for E. coli. The majority (63.6%) of the isolates were from female. Of the total 191 E. coli isolates were sensitive to levofloxacin 164 (85.8%), cefoperazone + sulbactam 160 (83.7%), Amikacin 160 (83.7%), Gentamicin 152 (79.5%), Imipenem150 (78%), meropenem150 (78%), Piperacillin-tazobactum 120 (71%), Ceftriaxone 74 (38.7%).The isolates showed high level of resistance to Amoxycillin-clavulanic acid (100%), Ceftriaxone 117(61%), Piperacillin-tazobactum 71(37.2%), Imipenem41 (22%), meropenem41 (22%), Gentamicin 39 (20.5%), cefoperazone +sulbactam 31(16.3%), Amikacin31 (16.3%), levofloxacin 27 (14.2%). The study revealed that a significant number of the urinary tract infections in our study subjects were caused by multiple drug resistant E. coli. The sensitivity pattern showed…
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