Hyperosmolarity of mouse urine confounds research in urinary tract infection
Abstract
Mice have been used as models of urinary tract infection (UTI) for decades and laid the basis for the fundamental understanding of UTI pathogenesis in humans. Here we report that the high urine osmolarity of mice impacts key aspects of Escherichia coli UTI pathogenesis and represents a confounder for the translation of results to humans. The authors report that the high urine osmolarity of mice impacts key aspects of Escherichia coli urinary tract infection (UTI), including bacterial filamentation and infectious potential, with important consequences for modeling human UTI in mice.
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