High Dose Antimicrobial Protocols for Canine Urinary Tract Infections
Abstract
Background: Treatment for canine urinary tract infections (UTI) typically consists of 7-14 days of empirically chosen antimicrobial drugs.Enrofloxacin is a veterinary approved fluoroquinolone (FQ) antimicrobial and is useful for treatment of canine UTI.Ciprofloxacin, the primary metabolite of enrofloxacin, contributes additive antimicrobial activity.Higher doses of FQs may inhibit the emergence of antimicrobial resistance.Objectives: 1) Determine if dogs with naturally occurring uncomplicated UTI have equivalent microbiologic cure with a high dose short duration protocol of enrofloxacin, compared to a standard antimicrobial protocol.2) Measure urine concentrations of enrofloxacin, and ciprofloxacin, following a 20mg/kg single oral dose in healthy dogs (n=6).Animals: Client-owned dogs with naturally occurring, uncomplicated UTI (n=38), and healthy dogs owned by students and staff of OSU-VMC (n=6).Methods: A multi-center clinical trial was conducted.Dogs were assigned to 1 of 2 groups in a randomized blinded manner.Dogs in group 1 received treatment with 18-20mg/kg oral enrofloxacin (Baytril®) once daily for 3 consecutive days.Dogs in Group 2 were treated with 13.75-25mg/kg oral amoxicillin-clavulante (Clavamox®) twice daily iii for 14 days.Urine and plasma concentrations of enrofloxacin and ciprofloxacin were measured following a single dose of 20mg/kg oral enrofloxacin in 6 healthy dogs.Results: Thirty-eight dogs completed the clinical trial.No difference in microbiologic…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 38 participants or records.
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