De Novo Myeloid Sarcoma of the Kidney: A Case Report and Literature Review of Clinical Features and Outcomes
Abstract
Myeloid sarcoma (MS) can manifest as a primary disease entity, known as de novo myeloid sarcoma, without the concurrent presence of acute or chronic myelocytic leukemia, myelodysplastic syndrome, or myeloproliferative neoplasm. It is crucial to approach suspected de novo myeloid sarcoma cases comprehensively to prevent misdiagnosis and ensure timely and accurate treatment. We report a case of de novo myeloid sarcoma involving the kidney in a 38-year-old female patient with a chief complaint of a rapidly enlarging palpable mass in the upper right quadrant for over a month. The patient's enhanced abdominal CT scan result was initially suspected to be renal cell carcinoma. Subsequently, we performed radical nephrectomy and post-operative pathology, immunohistochemistry, and cytogenetic analysis to confirm the diagnosis of de novo myeloid sarcoma. Histopathological analysis confirmed malignancy originating from the right kidney, accompanied by necrosis. The tumor cells displayed moderate size, evident pleomorphism, and off-centered granular cytoplasm. Extensive infiltration of the renal parenchyma was observed, involving the renal capsule, perirenal adipose tissue, and renal pelvis mucosa. CD117 displayed positive immunohistochemical staining. There is currently a dearth of studies that comprehensively describe de novo myeloid sarcoma involving the urogenital tract. In light of this gap in the literature, the present study aims to provide a systematic literature review and…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.