Comparison between in Vitro Activities of Solanium Aethiopicum and Rauwolfia Vomitoria Leaves Extract on Urinary Tract Infections (UTI) Isolates from Urine
Abstract
Urinary tract infections (UTI) are treated with antibiotics and untreated case could cause permanent damage of kidneys (pyelonephritis), however, pathogens of cystitis are fast becoming resistant to some antibiotics if not all. This resistance has increased the interest of medical researchers on herbal remedies that can serve as alternatives to conventional antibiotics; in line with this quest , this research x-rayed the effects of both ethanol and aqueous extracts of Solanium aethiopicum and Rauwolfia vomitoria leaves singly and in combination on hematological parameters, lipid profile, enzymatic antioxidant potentials and renal function test with a view to developing an effective antimicrobial agent for the treatment of urinary tract infection/ kidney diseases. Their efficacy of alternatives were evaluated by agar well diffusion and macro-broth dilution methods on 37 bacterial, and 6 fungal clinical urine isolates of E. coli, S. aureus, Psuedomonas aeruginosa, Candida albicans, Staphylococcus spp, Proteus marabilis, Candida and Klebsiella species. Activity of the ethanolic extract of the S. aethiopicum was significantly higher than the aqueous extract (P 5000mg of extract/mg body weight of albino rat. Results above justify their folkloric application in the treatment of urinary tract infection.
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