Combinatorial Effect of Antibiotics on Prevalent Microorganisms Causing Urinary Tract Infection
Abstract
Introduction: Urinary tract infection (UTI) is a common medical condition of urinary tract detected by the presence of threshold number 105 Colony Forming Unit per millilitre of pathogenic bacteria in the urine. This study aimed to determine the combinatorial effect of antimicrobials on the most prevalent microorganism causing UTI along with antibiotic susceptibility pattern.
Methods: Thirty-five bacterial isolates from patients diagnosed with UTI were collected from Manipal Teaching Hospital, Pokhara. The isolates were investigated using Standard Laboratory Procedures followed by Kirby-Bauer disc diffusion method for antibiotic susceptibility test and Double disc diffusion method for combinatorial effect.
Results: Out of 35 bacterial isolates, 30 (85.71%) isolates showed resistance pattern to the antibiotics where ampicillin and amoxicillin were the most resistant drug (82.9% each) in 29 isolates and the most sensitive drug was imipenem (82.9%) followed by amikacin (80.0%). The combinatorial effect of antibiotics against resistant isolates was observed using double disc diffusion method in which 10 (33.3%) Escherichia coli isolates out of 30 showed positive result against combination of cefotaxime+amoxicillin, levofloxacin amoxicillin, levofloxacin gentamicin and cefotoxamine+levofloxacin.
Conclusion: This study revealed that E. coli, the most prevalent bacteria causing urinary tract infection was highly resistant to ampicillin and amoxicillin. The resistant antibiotics…
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