Pathogen characteristics of different types of lower urinary tract infections and their in vitro susceptibility to antimicrobial agents in Chinese multiple centers
Abstract
Objective
To assess the pathogen characteristics of different types of lower urinary tract infections (UTIs) and their in vitro susceptibility to commonly used antibiotics in Chinese multiple center.
Methods
Multicenter study was conducted from January 2011 to December 2011 in 12 Chinese hospitals. Middle stream urine samples were collected from 350 afebrile patients, including 198 cases with acute uncomplicated cystitis, 82 cases with recurrent lower UTI and 70 cases with complicated antibiotic needed lower UTI. In those patients with positive urine culture, minimal inhibitory concentrations (MICs) of some antimicrobial agents were measured using broth microdilution after collecting the pathogen. ESBLs production was confirmed by a double–disk synergy test.
Results
198 urine samples were culture–positive and 175 isolates were included in the final analysis. Among the organisms cultured, 116(66.3%) were gram–negative bacterium and 59(33.7%) were gram–positive bacterium. To the acute uncomplicated cystitis, recurrent UTI and complicated UTI, the detection rates of E. coli were 53.1%, 50.0% and 40.5%, respectively. The rates of ESBL–producing E. coli were 49.0%, 57.1% and 60.0%, respectively. The rate of Enterococcus faecalis were 8.3%, 4.8% and 13.5%, respectively. Uropathogen's sensitivity rate of acute uncomplicated cystitis, recurrent lower UTI and complicated lower UTI to levofloxacin were 53.1%, 47.6% and 32.4%, respectively, The sensitivity rate of those groups to…
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