Asymptomatic Urinary Tract Infections in Patients with End Stage Renal Disease on Regular Hemodialysis
Abstract
Background: Isolation of a specific quantitative count of bacteria in an appropriately collected urine sample from a patient who does not exhibit any symptoms or signs indicative of an asymptomatic urinary infection. In this study, we aimed to estimate correlation between asymptomatic urinary tract infection and hemodialysis (HD)-dependent end-stage renal disease patients. Methods: Sixty patients with End Stage Renal Disease who were on long-term hemodialysis in this prospective cohort study were classified into 42 patients with positive pus in urine (70%) and 18 patients with non-pyuria (30%). Urina analysis, routine culture, and count of bacteria were assessed among other laboratory investigations in all patients. Results: Significant higher levels of erythrocyte sedimentation rate (ESR), C- reactive protein (CRP), and neutrophils levels among cases with pyuria versus cases with non-pyuria (p–value 0.032, 0.020, 0.046 respectively), the majority of culture and sensitivity are 11 patients (36.7%) for Levofloxacin followed by nine patients (30%) for Ciprofloxacin. Multivariate regression analysis revealed that most significant predictors of pyuria were DM, SBP (mmHg), ESR (mm/hr), CRP (mg/L), Neutrophils and Decrease Hb (gm/dL) with [OR (C.I.95%), p-value] [[1.855 (0.505- 5.679), p= 0.024; 1.761 (0.244- 4.600), p= 0.029; 1.061 (0.969- 3.742), p= 0.036; 1.790 (0.457- 6.823), p= 0.022; 1.981 (0.895- 3.460), p= 0.040 and 1.730 (0.422- 5.384), p= 0.025], respectively.…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 42 participants or records.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.