Antibiotic Prescriptions for Non-severe Urinary Tract Infections: A Single-Center Retrospective Study to Guide Antibiotic Stewardship
Abstract
Background: Urinary tract infections are common diagnoses in adult emergency departments and account for a substantial proportion of antibiotic prescriptions. Inappropriate antibiotic use contributes to bacterial resistance, underscoring the need for local antimicrobial stewardship efforts. Objectives: This study aimed to assess compliance of antibiotic prescriptions for non-severe urinary tract infections with national guidelines and to examine local resistance patterns. Methods: This single-center retrospective study analyzed data from the medical records of adult patients with acute, noncomplicated urinary tract infections who attended the emergency department at Amiens-Picardie University Medical Center, Amiens, France, between January 1, 2021, and December 31, 2023. Compliance with the guidelines issued by the French Infectious Diseases Society (Société de Pathologie Infectieuse de Langue Française, SPILF) was evaluated with respect to the antibiotic molecule, dosing regimen, and treatment duration. Statistical analyses included descriptive statistics, bivariate tests (chi-squared test, Fisher exact test, t-test, and Mann-Whitney U test), and multivariate logistic regression to identify factors associated with noncompliance. A P value < 0.05 was considered statistically significant. Variables with P < 0.20 in bivariate analysis were included in the multivariate model. Multicollinearity was assessed using the Belsley-Kuh-Welsch technique, and heteroskedasticity and…
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