Pathogenic profile and drug susceptibility in urinary tract infection during pregnancy: a retrospective hospital-based comparative cohort study
Abstract
Pregnant women are prone to urinary tract infection (UTI). Whether the pathogen spectrum and antibiotic resistance profiles of UTI differs between pregnant and non-pregnant women, as well as the sensitivity and drug resistance of pathogens to antibiotics, requires further clarification. Therefore, we aimed to compare the pathogen distribution and antibiotic resistance between pregnant and non-pregnant women with UTIs to provide evidence for the treatment of UTIs during pregnancy. From January 2016 to December 2023, 380 female inpatients aged 18 to 45 years who were clinically diagnosed with UTI in the nephrology department of our hospital were retrospectively analyzed. They were divided into pregnant and nonpregnant groups. The differences in etiology, drug sensitivity to antibiotics, drug resistance rates, complications and length of hospitalization between the two groups were analyzed. Of the 380 cases, pathogens were detected in 132, corresponding to a positive rate of 34.74%. Gram-negative bacteria were detected in 79 cases (59.85%). Among the 132 cases, 61 were positive for Escherichia coli (46.21%). There were 17 cases of extended-spectrum β-lactamase-positive E. coli, accounting for 27.87% of all E. coli cases. The resistance rates to ceftriaxone, ceftazidime, aztreonam, levofloxacin, cefoperazone/sulbactam and piperacillin/tazobactam were 44.26%, 29.51%, 27.87%, 26.23%, 1.64% and 0.00%, respectively, and the drug resistance rate to meropenem was 0.00%. Among the 187…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 187 participants or records.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.