Related factors of bloodstream infections associated with urinary tract infections and pathogenetic characteristics analysis
Abstract
OBJECTIVES: To explore correlations between biomarker indices and urosepsis severity, and investigate the prevalence of drug-resistant Escherichia coli in a patient population at the General Hospital of Ningxia Medical University in the Ningxia region of China. METHODS: Patients with urinary tract infection-associated sepsis were categorized into three groups: a septic non-shock group (NSSPU), a septic shock group (USG), and a control group with non-sepsis cases of simple urinary tract infections (CG). The study analyzed various biomarkers, including the percentage of neutrophils (N%), neutrophil-to-lymphocyte ratio (NLR), and lactate (La), to assess their predictive value for urogenital sepsis severity. RESULTS: The Kruskal-Wallis test showed significant differences in all measured biomarkers between the groups. ROC curve analysis identified N%, NLR, total protein (TP), albumin (ALB), and La as meaningful predictors of urosepsis severity. The combined detection indicators hold greater value in diagnosing uroseptic shock compared to individual test indicators. In addition, the study confirmed the prevalence of drug-resistant E. coli in cases of septic shock. CONCLUSION: The combined monitoring of N%, NLR, La, TP, and ALB proves beneficial in the clinical diagnosis of uroseptic shock. This study emphasizes the significance of monitoring Escherichia coli and its resistance patterns to decrease the occurrence of sepsis complications.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.