Bovine colostrum for prevention of recurrent urinary tract infections in susceptible children: A randomized controlled trial
Abstract
BACKGROUND Recurrent urinary tract infections (UTIs) in children with congenital anomalies of the kidney and urinary tract (CAKUT) are a major cause of deterioration of kidney functions and possibly, renal scarring. Rising antimicrobial resistance necessitates alternative preventive strategies. Bovine colostrum (BC), a bioactive prebiotic, has emerged as a promising adjuvant therapy in upper respiratory and gastrointestinal (GIT) infections. Given the shared mucosal immune mechanisms, the urinary tract may represent a suitable target for this preventive strategy to reduce UTI recurrence. AIM To evaluate the potential role of oral BC as an adjuvant therapy for preventing recurrent UTIs in children with CAKUT. METHODS This randomized, double-blinded, placebo-controlled trial enrolled 60 children ( 0.05). Colostrum supplementation showed a nonsignificant reduction in the overall incidence of upper and lower UTIs vs placebo over six months [relative risk (RR) = 0.84, 95%CI: 0.63-1.12; P = 0.22]. However, significant reductions of 73%-75% in UTI incidence were observed during the fourth, fifth, and sixth months of follow up (P < 0.05 for each). When stratified by infection type, cystitis incidence was significantly lower in the colostrum group (43.3% vs 70.0%; RR = 0.62; 95%CI: 0.39-0.99; P = 0.037), while no significant difference was observed in pyelonephritis. GTI and respiratory infections were reduced by 34% (RR = 0.66; 95%CI: 0.50-0.87; P = 0.001). No allergic reactions…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 60 participants or records.
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