A Randomised Controlled Trial: Evaluating the Effectiveness of Alkalinising Agent as Adjunct Therapy in Paediatric Urinary Tract Infection Management
Abstract
Introduction: Urinary tract infections (UTIs) are common in children, presenting with clinical symptoms and bacteri-uria. While antibiotics are the standard treatment, alkalinising agents like potassium citrate may help alleviate symp-toms more rapidly. This study evaluated the effectiveness of potassium citrate as an adjunct therapy for paediatric UTIs. Methods: This double-blinded, randomised controlled trial was conducted at a tertiary hospital to assess the benefits of potassium citrate in paediatric UTI treatment. Thirty-three children aged 1 month to 18 years diagnosed with UTIs were randomly assigned to receive either potassium citrate or a placebo alongside standard antibiotics. Results: Seventeen children received potassium citrate, and sixteen received a placebo. Baseline characteristics, in-cluding age, gender, and septic parameters (C-reactive protein [CRP], full blood counts [FBC], and urine pH), were similar between groups. The potassium citrate group showed a trend towards faster symptom resolu
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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