Antimicrobial Resistance in Companion Animals: A 30-Month Analysis on Clinical Isolates from Urinary Tract Infections in a Veterinary Hospital
Abstract
Simple Summary Antimicrobial resistance is a frequent finding during bacterial urinary tract infection in dogs and cats. This study evaluated bacterial species, antimicrobial resistance patterns and multi-drug resistance rate in clinical isolates of dogs and cats in a European veterinary university hospital; moreover, we evaluated multi-drug resistance trend in a long-term follow-up, applying the International Society for Companion Animal Infectious Disease urinary tract infections guidelines as a guide for antimicrobial stewardship. In our study, almost half of the cases were classified as upper urinary tract infection and recurrent cystitis; also, this study showed that antimicrobial resistance reached 75% of clinical isolates and the multi-drug resistance percentage was 37%, including resistance mostly against first-line antibiotics such as penicillins for sporadic cystitis and fluoroquinolones for pyelonephritis, respectively. Applying urinary tract infection guidelines during a 30-month period of follow-up, led to a significant decrease in multi-drug resistance. Our work highlights how the application of international urinary tract infection guidelines as a tool for antimicrobial stewardship can significantly reduce antimicrobial resistance in daily practice for a long-term follow-up; moreover, it emphasizes the bacteriological assessment as a fundamental examination for urinary tract infection treatment, guiding antibiotics prescription in an evidence-based manner to…
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