Comparative Evaluation of Infectious Potential, Resistance Patterns and Key Determinants of Escherichia coli in Urinary Tract Infection: A Cross-sectional Study
Abstract
Introduction: The emergence of Multidrug-Resistant (MDR) Escherichia coli (E. coli) and its opportunistic uropathogenicity complicates the treatment of Urinary Tract Infections (UTIs), consequently increasing healthcare costs and mortality rates. Uropathogenic E. coli (UPEC) is the primary cause of most UTIs, such as cystitis and pyelonephritis. These infections can lead to severe complications, including acute renal failure, affecting both healthy individuals and renal transplant patients.
Aim: To scrutinise the infectious prevalence of E. coli and the occurrence of UPEC, with relative proportional scrutiny of the resistance spectrum and determinants associated with UTIs to identify their management strategies.
Materials and Methods: This cross-sectional study was conducted between February 2019 and February 2023 at the Microbiology Laboratory of Charotar Hospital and Research Foundation (CHRF), Anand, Gujarat, India. A total of 461 clinical specimens, including 153 urine samples, were processed to determine the infectious magnitude of E. coli and the rate of UPEC. Their resistance spectrum and mechanisms were compared using disc diffusion assays and statistically analysed by Chi-square value, two-tailed p-value, odds ratios (ORs) and confidence intervals using Microsoft Excel 2021 and CDC Epi Info™ software by the US Department of Health and Human Services, Centres for Disease Control and Prevention.
Results: E. coli was predominant in UTIs, comprising 45% of UPECs. Of the…
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Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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