Prevalence, Risk Factors and Outcomes of Acute Kidney Injury among Hospitalized Patients with Urinary Tract Infection a Retrospective Cross-Sectional Study
Abstract
Objectives: Acute Kidney Injury (AKI) may be prevalent among patients with urinary tract infection, in the presence of certain risk factors. We aim to
identify the prevalence, risk factors and outcomes of AKI among that patient population.
Methods: A retrospective cross-sectional study was conducted. Hospitalized patients with urinary tract infection who had at least two serum
creatinine measurements were selected. The KDIGO definition of AKI was applied. The outcomes were baseline and discharge serum creatinine
changes, renal recovery, and requirement of dialysis and in-hospital mortality. Analysis was performed using the unpaired t-test, two sample t-test,
Pearson’s Chi square and binary logistic regression, as indicated.
Results: Sixty-four percent developed AKI in which 47% were found to have Stage I, 24.2% Stage II, 28.8% Stage 3 AKI and 64.6% regained serum
creatinine around their baseline. Younger age < 40 years had lower risk of AKI (ORs 0.36; 95% CI 0.190.67; p=0.001). Mean ± SD baseline serum
creatinine and discharge serum creatinine were significantly higher in UTI-AKI patients (63.2 ± 21.2 vs 97.1 ± 67.8 µmol/L (p=<0.001) and 62.5 ±
23.1 vs 130.9 ± 151.2 µmol/L (p=<0.001), respectively, with wider variance ratio (p=<0.001). A higher risk of AKI was observed in patients with CKD
and ICU admission. (ORs 11.4; 95% CI 1.46, 88.97; p=0.020, ORs 9.6; 95% CI 1.15,80.25; p=0.036, respectively). Usage of antihypertensives and
PPIs increased the risk of AKI (95% CI 1.08,…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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