Association of TNF-α and microRNAs expression with immune cell profiles and kidney function in women with urinary tract infection: A cross-sectional study
Abstract
Urinary tract infection (UTI) is associated with inflammatory activation involving cytokines and microRNAs (miRNAs). However, the relationship between tumor necrosis factor-alpha (TNF-α), miRNA expression, immune cell profiles, and renal function remains unclear. The present study aimed to evaluate TNF-α, miR-125, and miR-155 expression in women with UTI and assess their association with immune cell profiles and kidney function.
Methods. This cross-sectional study included 123 women with culture-confirmed UTI and 40 healthy controls. Hematological and biochemical parameters were measured, and expression levels of TNF-α, miR-125, and miR-155 were assessed using qRT-PCR. Correlation analysis was performed to evaluate associations between molecular markers, immune cell profiles, and kidney function.
Results. TNF-α, miR-125, and miR-155 expression levels were all significantly higher in UTI patients compared with controls (all p 0.05).
Conclusions. TNF-α is associated with microRNA expression in UTI. microRNAs show stronger relationships with immune cell profiles, while neither TNF-α nor microRNAs is associated with kidney function.
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 155 participants or records.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.