Correlation between Vitamin D Levels and Recurrent Lower Respiratory Tract Infection in Children: A Cross-sectional Study
Abstract
Introduction: Vitamin D is a vital nutrient with immunomodulatory effects that may impact susceptibility to infections. Lower Respiratory Tract Infections (LRTI) are among the leading causes of morbidity and mortality in children. However, there is limited research exploring the relationship between vitamin D levels and LRTI in children in India.
Aim: To find a correlation between vitamin D levels and recurrent LRTI in children aged 6 months to 5 years.
Materials and Methods: A cross-sectional study was conducted in the Pediatric ward of Bokaro General Hospital in Jharkhand, India, between June 2019 and May 2020. A total of 222 children aged 6 months to 5 years diagnosed with recurrent LRTI were enrolled as cases (n=111), while other children in the same age group who were admitted with different diagnoses and required blood sampling were enrolled as controls (n=111) after obtaining parental consent. The blood levels of 25-hydroxy vitamin D [25(OH)D] were estimated and compared for both groups. Qualitative data were analysed using the chi-square test, while the Pearson’s correlation coefficient was used to compute the correlation between quantitative variables.
Results: Among a total of 222 children, the majority 53 (47.7%), exhibited Vitamin D Deficiency (VDD), while most controls, 44 (39.6%) had normal vitamin D levels (p-value=0.03). The mean vitamin D level in the case group was significantly lower (p-value=0.022) compared to the control group. The VDD was found in 36…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 222 participants or records.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.