Dysmotility In Gastrointestinal And Urinary Tract In A Neonate; Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome; A Case Report
Abstract
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome (MMIHS) is a rare disorder characterized by smooth muscle dysfunction impairing the intestine and bladder. This disorder is commonly associated with a fatal prognosis. Here, we present a female neonate with antenatal clues who had abdominal distension since birth and underwent multiple exploratory laparotomies, and bladder distension requiring drainage by catheterisation. Unresponsive surgical procedures for bowel decompression were carried out. She was managed with total parenteral nutrition and jejunostomy. Mutation in the smooth muscle gamma-actin (ACTG2) gene confirmed the diagnosis. A timely high index of suspicion is crucial for neonates, especially females with abdominal and urinary distension. The early multidisciplinary assesment of the patient provides appropriate treatment modalities, and improves the survival.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.