Knowledge and practice in using the antimicrobial susceptibility test towards enterobacteriaceae isolated from urinary tract infection
Abstract
Background and aims: Antimicrobial resistance (AMR) is recognized as an urgent worldwide problem, particularly in developing countries like Yemen. Clinical microbiology laboratories play an essential role in guiding appropriate antimicrobial therapy through antimicrobial susceptibility testing (AST). This study aims to assess the knowledge and practices of antimicrobial susceptibility testing in public and private laboratories in Sana’a, Yemen, focusing on bacterial isolates from urinary tract infections (UTIs).
Materials and Methods: A cross-sectional study was conducted, analyzing 220 AST reports on positive urine cultures from public and private laboratories in Sana’a. The appropriateness of antimicrobial agent selection for testing and reporting susceptibility results was evaluated against CLSI M100-Ed32, 2022 guideline. Additionally, a standardized questionnaire was used to assess laboratory personnel's knowledge and practices related to AST.
Results: The study identified significant discrepancies in antimicrobial susceptibility testing and reporting practice between private and public laboratories in Sana'a, Yemen. Findings indicate a significant gap in the adherence to CLSI guidelines, with low testing and reporting rates for primary appropriate antimicrobial agents and over-reporting of inappropriate agents.
Conclusions: The study identified significant gaps in knowledge and adherence to international AST standards. Selective reporting is not being implemented.…
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