An emerging uropathogenic threat: high-virulence, stress-adapted, and drug-resistant pseudomonas aeruginosa from clinical UTI iraqi isolates
Abstract
Objective: Pseudomonas aeruginosa is one of the most important urinary tract infection-causative pathogens that is greatly associated with Urinary Tract Infections (UTI) because of its great ability to adaptation at different harsh environments due to the presence of a set of genes that contribute to the expression of virulence factors and the development of antibiotic resistance. The present study aimed to phenotypically characterize the multidimensional phenotypic profile of Pseudomonas aeruginosa isolated from UTI Iraqi patients. Methods: Attachment and biofilm formation, blood hemolysis, urease, lipase, gelatinase, protease, and siderophores producing all were evaluated as virulence factors. Isolates' tolerance to harsh conditions, including heat, cold, salt, acid, and alkaline, was estimated. Antibiotic susceptibility test have been performed to assess isolates resistance against pipracillin, ceftazidime, cefepime, azteronam, imipenem, meropenem, amikacin, gentamicin, tobramycin, levofloxacin and colistin. Results: Results explain that the majority of isolates had a concurrent presence of virulence traits and the ability for antibiotic resistance and tolerance to harsh conditions. Novelty: which indicate that Pseudomonas aeruginosa represents an emerging uropthological threat characterized by high adaptive flexibility and virulence, which further complicates therapeutic options and underscores the need for continuous surveillance and more stringent preventive and…
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