Abstract 4369642: Efficacy of Sodium-Glucose Transport Protein 2 Inhibitors in Prevention Atrial Fibrillation post - Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-Analysis
Abstract
Introduction:
Atrial fibrillation(AF) following coronary artery bypass graft is a prevalent complication often occurring 2-4 days postoperatively, characterised by brief asymptomatic episodes. It increases morbidity, hospital stay, risk of stroke and mortality. The pathophysiology involves triggers that act on a susceptible remodelled-atrium. Risk factors include age, heart failure, hypertension and atrial enlargement. Emerging evidence indicates Sodium-Glucose Transport Protein 2 Inhibitors (SGLT2i) like empagliflozin may prevent post-Coronary Artery Bypass Graft Surgery (CABGs) associated AF by reducing sympathetic outflow, atrial remodelling and inflammation. Considering these mechanisms and existing data we have developed this study to assess the potential of SGLT2i in preventing postoperative atrial fibrillation in patients undergoing coronary artery bypass graft.
Methodology:
The review conducted follows the PRISMA guidelines and major medical databases, which include PUBMED, Google Scholar and Science-Direct, were extensively searched using a comprehensive search term to identify and retrieve available articles. The articles that included the assessment of the efficacy of SGLT2i in the prevention of AF post-CABGs were considered for the final analysis.
The data was analysed using the Meta, Metadata and the Metafor packages of R Studio. The Odds Ratio of occurrence of Atrial Fibrillation was assessed as the primary outcome. The Mantel-Haenszel method (Common effect…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 6,011 participants or records.
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