Antibiotic Sensitivity of Frequently Isolated Bacteria From Urinary Tract Infection in Cancer Patient: An Analysis from a Tertiary Cancer Hospital in Nepal
Abstract
Introduction: Urinary tract infection is the most common infection in cancer patients. Anti-microbial resistance is an emerging issue worldwide. Increasing evidence shows the incidence of multi-drug resistant (MDR) strains of bacteria causing urinary tract infections in cancer patients. This study aims to determine the antibiotic sensitivity pattern of frequently isolated bacteria from urinary tract infections in cancer patients.
Methods: A retrospective analysis was carried out on the data of positive urine cultures from patients diagnosed with various cancers between September 2020 to June 2024 at a tertiary cancer hospital in Nepal. Data on the patient’s age, sexand diagnosis were collected. Positive urine culture data were acquired from the electronic record system of the Medical Laboratory. Antibiotic sensitivity testing was performed using the Kirby-Baur disk diffusion method. Data were analyzed using R-statistical software (version 4.4.0)
Results: A total of 102 positive urine cultures from 97 patients were analyzed. The median age of the cohort was 58 years (range: 19–94). Gynecologic cancer was the most common type (46.39%), followed by genitourinary, central nervous system, lung, and other cancers. The most frequently isolated bacteria causing urinary tract infections were Escherichia coli (59.80%), Klebsiella pneumoniae (13.73%), Pseudomonas aeruginosa (8.82%), and Staphylococcus spp. (6.86%).
Conclusion: With the global rise of antibiotic resistance, real-world…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 97 participants or records.
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