Efficacy and safety of ureteral stenting in kidney transplant: a systematic review and meta-analysis of randomized clinical trials
Abstract
Introdução: Kidney transplantation (KT) is an excellent treatment option for patients with chronic kidney failure. In this context, the use of renal stents has been associated with improved nephrological and urological outcomes and may contribute to a reduction in long-term allograft loss. Recently, a randomized controlled trial (RCT) provided new insights into the benefits of stenting in transplant recipients. Therefore, we conducted a meta-analysis to synthesize the available evidence and reduce uncertainties regarding the impact of this technique in KT.
Métodos: We systematically searched PubMed, Embase, and Cochrane Library, for RCTs comparing stent group versus no stent group for kidney transplant postoperative management. The outcomes of interest were urinary leak, ureteral obstruction and urinary tract infection (UTI) rates. We pooled analysis of odds ratio (OD) with 95% confidence intervals applying a random-effects model and using Review Manager 5.4.1 for all statistical analyses.
Resultados: We included 9 RCTs comprising 1392 patients, 721 patients in the stent group and 671 patients in no stent group. The analysis showed that the stent group had fewer cases of urinary leak (OD = 0.23 [0.10 – 0.53]; p< 0.01; I² = 5%) and obstruction (OD = 0.27 [0.10 – 0.73]; p<0.05; I² = 0%). In contrast, the no stent group had lower rates of UTI (OD = 2.12 [1.08 – 4.17]; p<0.05; I² = 70%).
Discussão e Conclusões: Our findings provide new evidence that stenting during KT…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 1,392 participants or records.
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