Antimicrobial interventions in multi drug resistance providencia associated infection; a systematic review and meta-analysis of case reports
Abstract
Providencia infections are rare but emerging clinical entities with limited published evidence. We performed a pooled descriptive analysis by extracting data from case reports and case series to elucidate the clinical characteristics, outcomes, and potential predictors of adverse events. A total of 69 cases of Providencia infection were analyzed (mean age: 52.77 ± 21.04 years; 61.19% male). Descriptive statistics were used to summarize patient demographics, clinical characteristics, and infection types. Complete-case data were used for regression analyses specifically, 63 cases for the sepsis outcome, 64 cases for urinary tract infections (UTIs), 62 cases for tracheal aspirates (TAs), and 46 cases for mortality. Logistic regression models with cluster-robust standard errors were applied to account for intra-study dependencies. Variables were selected for multivariable modeling using a backward stepwise approach with a p-value threshold of ≤ 0.3. The overall in-hospital mortality was 20.0% (13/69). The predominant infection types were bloodstream infections (sepsis) in 21 cases (30.43%), UTIs in 18 cases (26.09%), and surgical site infections in 17 cases (24.64%). In multivariable regression analysis, the experience of shock during hospitalization emerged as a significant predictor of poor outcome; patients who experienced shock had an adjusted odds ratio of 5.57 (95% confidence interval: 1.26–24.61, p = 0.023) for adverse events. Other factors, such as gender, underlying…
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