Clinical, phenotypic, and genotypic characteristics of ESBL-producing Salmonella enterica bloodstream infections from Qatar
Abstract
Resistant Salmonella infections is a major global public health challenge particularly for multidrug resistant (MDR) isolates manifesting as bloodstream infections (BSIs). To evaluate clinical, phenotypic and genotypic characteristics of ESBL producing Salmonella enterica bloodstream infections from Qatar. Phenotypic ESBL Salmonella enterica collected from adults’ patients presenting with positive BSIs were collected between January 2019-May 2020. Microbiological identification and characterization were performed using standard methods while genetic characteristics were examined through whole genome sequencing studies. Out of 151 episodes of Salmonella enterica BSI, 15 (10%) phenotypic ESBL isolates were collected. Recent travel was recorded in most cases (80%) with recent exposure to antimicrobials (27%). High level resistance to quinolines, aminoglycosides and cephalosporins was recorded (80-100 %) while meropenem, tigecycline and colistin demonstrated universal susceptibility. Genomic evaluation demonstrated dominance of serotype ST1 (93 %) while antimicrobial resistance genes revealed dominance of aminoglycoside resistance (100 %), qnrS1 quinolones resistance (80%), blaCTX-M-15 ESBLs (86.7 %), and paucity of AmpC resistance genes (6.7%). Invasive MDR Salmonella enterica is mainly imported, connected to patients from high prevalent regions with recent travel and antimicrobials use caused by specific resistant clones. In suspected cases of multidrug resistance, carbapenems…
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