A Review on Gastroesophageal Reflux Disease
Abstract
Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal disorder caused by the abnormal reflux of gastric contents into the esophagus, resulting in symptoms and potential mucosal injury. Its pathogenesis involves lower esophageal sphincter dysfunction, impaired esophageal clearance, delayed gastric emptying, and exposure to acidic and nonacidic refluxate. GERD presents as erosive or non-erosive disease, with varying risks of complications such as Barrett’s esophagus. Management includes lifestyle modifications and pharmacological therapy, with proton pump inhibitors as firstline agents. Emerging therapies, including potassium-competitive acid blockers, offer alternative approaches. This review highlights the epidemiology, pathophysiology, clinical features, and current treatment strategies for GERD.
Read the paper
Related studies
- Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use
- Ivth brazilian consensus conference on helicobacter pylori infection
- A pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia
- S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – März 2023 – AWMF-Registernummer: 021–013
- Step-by-step management of refractory gastresophageal reflux disease
- Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.