Gastroesophageal reflux disease and upper aerodigestive tract cancer risk: A meta-analysis of site-specific associations
Abstract
e18106
Background:
Gastroesophageal reflux disease (GERD), which affects approximately 20% of the U.S. population, has been implicated as a potential risk factor for upper aerodigestive tract (UADT) cancers, such as laryngeal cancers. This systematic review and meta-analysis aimed to evaluate the association between GERD and UADT cancers.
Methods:
A systematic review and meta-analysis were conducted to assess the relationship between GERD and UADT cancers. Random-effects models were used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs) for site-specific associations.
Results:
A total of 17 studies were included, including 12 case control studies and 5 cohort studies. Meta-analysis revealed a significant association between GERD and laryngeal cancer (RR = 1.65, 95% CI = 1.19–2.31, n = 14). Subgroup analysis of laryngeal cancer studies demonstrated a stronger association in cohort studies (RR = 2.41, 95% CI = 1.21–4.80, n = 3) compared to case-control studies (RR = 1.50, 95% CI = 1.10–2.06, n = 11). Geographic differences were also observed, with studies in the U.S. showing a significant association (RR = 1.65, 95% CI = 1.23–2.23, n = 8) compared to those conducted outside the U.S. (RR = 1.70, 95% CI = 0.86–3.36, n = 6). No significant associations were observed for pharyngeal cancer (RR = 1.40, CI = 0.74 –2.67), oropharyngeal cancer (RR = 1.91, 95% CI = 0.30–12.33, n = 3), hypopharyngeal cancer (RR = 2.05, 95% CI = 0.25–16.54, n = 3), or esophageal…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 14 participants or records.
Read the paper
Related studies
- Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use
- Ivth brazilian consensus conference on helicobacter pylori infection
- A pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia
- S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – März 2023 – AWMF-Registernummer: 021–013
- Step-by-step management of refractory gastresophageal reflux disease
- Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.