S482 Evaluating Multiple Dosing Regimens for Proton Pump Inhibitors (PPI) for the Treatment of Gastroesophageal Reflux Disease (GERD): A Systematic Review and Meta-Analysis
Abstract
Introduction: Although once-daily dosing of PPI therapy for GERD is standard of practice, clinicians often use twice daily dosing. It remains unclear if this common practice meaningfully improves GERD symptoms of heartburn and/or regurgitation. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) assessing for resolution of GERD, heartburn, and esophageal healing with regards to various PPI dosages and frequencies. Methods: A search of EMBASE and PubMed in October 2021 yielded 1381 unique records. Abstract/title screening and full-text review were completed by two independent reviewers, where 51 studies were included in thesystematic review and 37 RCTs were included in the quantitative analysis; all included studiescompared di ff erent doses within PPI. Dataabstraction wasperformed in duplicate using Systematic Review Data Repository 1 , with discrepancies resolved by a third reviewer. The outcomes were resolution of GERD, heartburn, and esophageal healing within 12 weeks. Risk of bias was independently assessed using the Cochrane Risk of Bias tool (v2). Random-e ff ects meta-analyses were conducted in Stata. Studies were excluded from quantitative review if they did not report outcomes of interest, only assessed outcomes after 12 weeks, or compared out-of-practice dosages (quarter and quadruple standard dose). Results: A totalof 51RCTsconductedacross27countries(n compared Introduction: Patients experiencing laryngeal symptoms such as…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 8 participants or records.
Read the paper
Related studies
- Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use
- Ivth brazilian consensus conference on helicobacter pylori infection
- A pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia
- S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – März 2023 – AWMF-Registernummer: 021–013
- Step-by-step management of refractory gastresophageal reflux disease
- Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.