Esophageal Motility Outcome after Nissen Fundoplication: A Systematic Review and Meta-Analysis
Abstract
Background: Gastroesophageal reflux disease (GERD) is a very prevalent disease. The Montreal consensus conference in 2006 defined GERD as "a condition which develops when the re-flux of gastric contents causes troublesome symptoms and/or complications". The pathophysiology of GERD is multifactorial and complex but revolves around an incompetent esophago-gastric junction (EGJ) as an anti-reflux barrier, in the form of transient lower esophageal sphincter relaxations (TLESR) and/ or a hypotensive EGJ. Aim of Study: To evaluate the efficacy of laparoscopic surgeries with regard to esophageal motility and determine a clear indication for these interventions. Additionally, we will compare between preoperative and postoperative manometer results. Patients and Methods: This systematic review and meta-analysis was conducted by careful following of the Cochrane handbook for systematic reviews interventions and the results were described according to the Preferred Reporting Items for Systematic reviews and Meta-analysis (PRISMA) statement. The
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Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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