Gastroesophageal Reflux Disease and Sleeves Gastrectomy with Different Distance to the Pyloric: A Systematic Review and Meta-Analysis
Abstract
Objective: This systematic review and meta-analysis was performed to explore the relationship between the distance of the pyloric and Gastroesophageal Reflux Disease (GERD) after Sleeves Gastrectomy (SG). Methods: A computerized literature search was conducted on PubMed, EMBASE, CENTRAL, and four Chinese databases for clinical studies from inception to December 2019. Data were pooled using Review Manger 5.3, and Odds Ratio (OR) with corresponding 95% Confidence Interval (95% CI) was pooled when needed. Subgroup and sensitivity analyses were performed if necessary and feasible. Results: Twenty-three articles with a total of 4,033 patients were included. Among these studies, 12 showed an increased prevalence of GERD after SG, while 11 showed a reduced prevalence. However, the pooled result showed non-significant relation between the distance of the pyloric and GERD. Additionally, there was no significant relation between rate of the esophagitis and the distance. Conclusion: No significant relation was found between distance of the pyloric and GERD after SG, as well as between the distance and esophagitis. But due to the high heterogeneity of the included studies, further prospectively designed studies are needed to confirm our founding. Chan Chen2#, Tsz Hong Chong1#, Bingsheng Guan1#, Juzheng Pen1, Wei Huang2# and Jingge Yang1* 1Department of Gastrointestinal Surgery, First Affiliated Hospital of Jinan University, China 2The Endoscopy Centre of the First Affiliated Hospital of…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 4,033 participants or records.
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