The Analysis Study of Histopathologic Diagnosis of Gastroesophageal Reflux Disease: An Anatomic Pathology Comprehensive Systematic Review
Abstract
Introduction : This systematic review explores the histopathologic features of GERD and its differential diagnoses, emphasizing the role of endoscopic and histologic assessments in clinical practice. Methods : A systematic review was conducted following PRISMA 2020 guidelines to evaluate the histopathologic features of GERD and its differential diagnoses. Results : From an initial pool of 6006 publications, eight studies were identified as directly relevant after a thorough screening process. The findings highlight the importance of biopsy sampling and histologic evaluation in differentiating GERD from other esophageal inflammatory conditions. Key diagnostic features included basal cell hyperplasia, elongation of lamina propria papillae, and dilatation of intercellular spaces, which were critical for distinguishing GERD from other conditions. Conclusion : This systematic review emphasizes the importance of histopathologic evaluation in the accurate diagnosis of GERD and its differential diagnoses. Understanding the distinct histopathologic features of GERD, as well as technical aspects of biopsy sampling, is essential for improving diagnostic accuracy and preventing progression to severe complications.
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use
- Ivth brazilian consensus conference on helicobacter pylori infection
- A pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia
- S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – März 2023 – AWMF-Registernummer: 021–013
- Step-by-step management of refractory gastresophageal reflux disease
- Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.