S611 Glucagon-Like Peptide Receptor Agonist (GLP-1 RA) Use is Not an Independent Predictor of Gastroesophageal Reflux Disease (GERD) on Quantitative Reflux Testing
Abstract
the liver, lungs, bone, and brain. However, esophageal metastasis from primary breast cancers is a rare phenotype, representing 0.6 % of esophageal malignancies. This descriptive study consolidates the 33 recorded cases of secondary esophageal cancer from breast cancer metastasis to better develop a framework for clinical management. Methods: We conducted a systematic review of literature on PubMed through January 2024 with the following grouped search terms: breast cancer, metastasis (or metastatic), and esophagus (or esophageal); secondary esophageal cancer and breast cancer. 338 results were obtained. Further selection was designated by restricting to only full case reports in the English language with human subjects. This yielded 60 studies. 27 cases were removed due to the inclusion of children ( , 18 years of age) or irrelevance (not secondary breast metastasis). Results: Theaverage age of participants was 64.39 6 11.8 years with symptom onset 12.29 6 6.28 years after the primary diagnosis(breast cancer). Dysphagia was the most commonly reported symptom (93.9 %). 40 % of patients had a lobular carcinoma, while 53.3 % had a ductal carcinoma. Histology revealed positive estrogen (84.2 %) and progesterone (57.9 %) receptors, among others. The secondary lesion was consistentlyfoundinthethoracicesophagus(93.9%).Endoscopy(40.6%) andEUS-FNA(37.5%)playedsigni fi cantrolesinestablishingadiagnosis.Treatmenttypicallyconsistedofhormonetherapy(41.4%), surgery (44.8 %), and…
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