What we know about gastroesophageal reflux disease and obstructive sleep apnea?
Abstract
ABSTRACT Objectives: The primary objective of this systematic review is assessing whether treatment of gastroesophageal disease (GERD) may reduce the apnea and hypopnea index (HAI) and the secondary objective of assessing whether there is a correlation between the HAI and gastroesophageal acid reflux. Methods: Using a systematic review of clinical studies that investigated the relationship between obstructive sleep apnea and GERD. The search included all cited publications up to April 22, 2012, using the keywords “sleep apnea, obstructive” AND “gastroesophageal reflux/diagnosis” OR “gastroesophageal reflux/drug therapy” OR “gastroesophageal reflux/therapy” AND “randomized controlled trial”. The following electronic databases were used: PubMed, EMBASE, LILACS, MedLine, SCISEARCH, WEB of Science, CINAHL, BIREMI, SCOPUS, and the database of controlled clinical trials of the COCHANE collaboration. The total sample size was 60 patients (55% males). All patients in the eligible studies were submitted to both polysomnography and esophageal pH measurements before and after treatment. Results: Initially, 24 articles were selected. Of these, only three met the criteria for this study All the 3 studies found in this analysis were “before and after” clinical trials. Through the grouping of patients in our systematic review, we found a statistically significant decline in the average time of GERD after treatment, and a trend for reduction in the rate of HAI. Conclusion: The studies…
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