PD06.06. The Effect of Gastroesophageal Reflux Disease on EndoFlip Parameters: A Retrospective Cohort Study
Abstract
Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia
Gastroesophageal reflux disease (GERD) is a condition often diagnosed via pH testing or endoscopy. The esophagogastric junction (EGJ) distensibility, measured by EndoFLIP, has been suggested as a potential biomarker for GERD. We aimed to evaluate whether adults with objectively confirmed GERD have higher EGJ distensibility compared to individuals without GERD
A retrospective cohort study was conducted involving 86 adults (50 cases with GERD and 36 controls without GERD, confirmed negative by pH testing). GERD patients were defined as having either positive pH testing or objective evidence of GERD on endoscopy following Lyon Consensus 2.0 criteria. Patients with prior fundoplication, bariatric, or esophageal surgery were excluded from the study, as well as those diagnosed with major motility disorders, such as achalasia. Primary outcomes included the EGJ distensibility index (EGJ-DI, mm2/mmHg) and EGJ distensibility category (normal, reduced, inconclusive). Secondary outcomes included maximum EGJ opening diameter and contractility patterns. Demographics, BMI, hiatal hernia presence, and PPI use were also recorded. Statistical analyses were performed using t-tests, chi-square tests, and ANCOVA, controlling for sex.
The average age of participants was 50.7±15.5 years, with cases averaging 52.8±14.2 years and controls 47.9±17.0 years (p=0.15). Gender distribution differed significantly between groups (p=0.0049), with…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 86 participants or records.
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