Anti-reflux mucosectomy superior to argon plasma coagulation in managing Barrett’s esophagus by improving lower esophageal sphincter pressure and cardiac sphincter valve function: a single-center, retrospective study
Abstract
Background: Barrett’s esophagus (BE) is a premalignant condition, caused principally by gastroesophageal reflux disease (GERD). Anti-reflux mucosectomy (ARMS) is an effective endoscopic treatment for GERD-related BE, utilizing scar tissue in the area of the esophagogastric junction, narrowing the gastric cardia. Thus, an anti-reflux barrier is formed, which obstructs the reflux of gastric contents into the esophagus. Objectives: Therefore, in this study, we investigated whether GERD-related BE improved post-ARMS by analyzing the changes in lower esophageal sphincter (LES) pressure, Hill’s classification for GERD, and GERD-related questionnaires. Design: In this retrospective study, we observed whether ARMS was superior to argon plasma coagulation (APC) in the management of GERD disease-related BE. Methods: Ninety-five patients were grouped into two cohorts, with 43 and 52 in the ARMS and APC cohorts, respectively. Four GERD-related questionnaires were administered. The anxiety self-rating scale (SAS) and depression self-rating scale (SDS) were used for the psychological evaluation of both cohorts. Endoscopic manifestations of BE were observed, and Hill’s classification for GERD was employed. Moreover, high-resolution esophageal manometry was performed to test esophageal motility. The follow-up period was 6 months post-treatment. Results: Greater statistically significant improvements in the four GERD-related questionnaires and SAS and SDS scores were observed post-ARMS than…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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