Risk factors for the formation of gastroesophageal reflux disease and erosive lesions of the esophagus in adolescents
Abstract
Background. Gastroesophageal reflux disease (GERD) is a common chronic relapsing disease of the upper digestive tract, both among adults and children and adolescents. Among the adult population, this disease is most often detected in people older than 60, while in children, a significant increase in its prevalence is noted with age, with a maximum in adolescents. GERD is characterized by a long-term course, polymorphism of clinical (esophageal and extraesophageal) manifestations, often subtle (which causes patients to seek medical help late), and can lead to the development of severe complications (erosive-ulcerative reflux esophagitis, Barrett’s esophagus, adenocarcinoma) and even sudden death in children. Therefore, it is important to identify risk factors (RF) for the development of GERD and destructive lesions of the esophagus in order to timely diagnose the disease and improve the effectiveness of its treatment. The authors provide up-to-date data on the RF for GERD in adults and children. However, in available scientific literature, there is practically no information on statistically significant combinations of RF for both GERD and destructive lesions of the esophageal mucosa in adolescents, which determined the need to conduct this study. The purpose was to find out the statistically significant RF for GERD and destructive lesions of the esophageal mucosa in adolescents and to develop the corresponding prognostic mathematical models. Materials and methods. To…
Read the paper
Related studies
- Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use
- Ivth brazilian consensus conference on helicobacter pylori infection
- A pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia
- S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – März 2023 – AWMF-Registernummer: 021–013
- Step-by-step management of refractory gastresophageal reflux disease
- Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.