Biomarkers of Aspiration in Gastroesophageal Reflux-Related Respiratory Disease: A Scoping Review
Abstract
PURPOSE
The link between gastroesophageal reflux disease (GERD) and pulmonary damage caused by recurrent aspiration is becoming clearer; however, clinical identification remains challenging. We conducted a scoping review to summarize research on diagnostic biomarkers for detecting aspiration in GERD-related respiratory diseases.
METHODS
We conducted a literature search for articles published from January 1998-November 2024 via MEDLINE, ScienceDirect, the Cochrane Library, Taylor & Francis, and ClinicalTrials.gov. Articles on biomarkers for detecting GERD-related aspiration in patients with chronic cough, asthma, idiopathic pulmonary fibrosis, and allograft rejection were included. Non-peer reviewed studies, case reports, small case series, and studies on other respiratory conditions were excluded. Two reviewers confirmed the eligibility of the screened publications. The research landscape was mapped, and co-authorship network analysis was performed. The potential for biomarker translation into clinical practice was assessed using six "ideal" characteristics.
RESULTS
Sixty-eight publications were included: 18 narrative reviews (26.5%), 7 pre-clinical studies (10.3%), and 43 clinical studies (63.2%). Within these studies, 126 biomarkers were identified (molecular or biochemical [65.1%], physiological [12.7%], genetic [9.5%], histological [8.7%], and radiological [4%]). Only 18 (14.3%) were rated as highly valuable for translation. The research network analysis revealed a lack…
Read the paper
Related studies
- Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use
- Ivth brazilian consensus conference on helicobacter pylori infection
- A pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia
- S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – März 2023 – AWMF-Registernummer: 021–013
- Step-by-step management of refractory gastresophageal reflux disease
- Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.