Sponge cytology combined with endoscopy in patients with long-segment Barrett’s esophagus: A retrospective case series and literature review
Abstract
This study summarized the clinical characteristics and endoscopic findings in patients with long-segment Barrett’s esophagus through a retrospective analysis of the clinical data of three patients with long-segment Barrett’s esophagus. Data from patients, including demographic characteristics, medical history, endoscopy findings, pathological diagnosis, and esophageal sponge cytology results were analyzed, and a literature review was performed. Three patients were included; all were male with a mean age of 67.3 ± 7.1 years. Symptoms encompassed heartburn (3/3), acid reflux (2/3), belching (1/3), retrosternal pain (1/3), abdominal distension (1/3), and dysphagia (1/3). Risk factors included alcohol use (3/3), consumption of pickled and hot foods or beverages (3/3), smoking (1/3), and familial esophageal disease history (1/3). Endoscopically, Prague C & M criteria measurements were C13M15, C4M10, and C6M7, with long-segment Barrett’s esophagus lesions spanning the upper/middle/lower esophagus; all showed circumferential involvement and coexisted with gastroesophageal reflux disease. Concurrently, two patients presented with all the following three conditions: hiatal hernia, chronic atrophic gastritis, and Helicobacter pylori infection. Pathologically, one patient showed early intramucosal adenocarcinoma, whereas two had intestinal metaplasia. Sponge cytology identified grade 3 atypical cells in one patient and grade 2 hyperplasia in two patients. In conclusion, long-segment…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use
- Ivth brazilian consensus conference on helicobacter pylori infection
- A pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia
- S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – März 2023 – AWMF-Registernummer: 021–013
- Step-by-step management of refractory gastresophageal reflux disease
- Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.