Fusobacterium necrophorum Brain Abscess With Concurrent Nasopharyngeal Detection of Mycoplasma pneumoniae: A Case Report
Abstract
Fusobacterium necrophorum is a recognized cause of brain abscesses and has been classically associated with Lemierre syndrome. We report a case of a 17-year-old male patient who presented with seizures, fever, and altered mental status following treatment for sinusitis. Neuroimaging revealed a right frontal lobe abscess requiring surgical drainage. Anaerobic cultures from the abscess fluid grew F. necrophorum, while a respiratory polymerase chain reaction (PCR) panel from a nasopharyngeal swab detected Mycoplasma pneumoniae. Anaerobic cultures also yielded Paenibacillus barengoltzii from a separate soft tissue specimen, though its clinical significance remained uncertain. The patient improved with surgical drainage and targeted antimicrobial therapy. This case highlights concurrent detection of F. necrophorum and M. pneumoniae in a central nervous system infection and underscores the uncertainty regarding the pathogenic role of M. pneumoniae in such presentations.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Photochemical behavior of levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.