Potential Risks and Drawbacks of Long-Term Proton Pump Inhibitors Use
Abstract
In today's world, proton pump inhibitors (PPIs) are one of the most commonly prescribed pharmacological types. Many gastrointestinal diseases such as gastroesophageal reflux or Barrett's esophagus, as well as laryngopharyngeal reflux, may benefit from these. However, numerous studies have been published that link PPIs to a variety of dangers and problems, including bone fractures, infection, myocardial infarction, renal illness, and dementia. By examining key articles and addressing the debates around those findings, this review exposes several of these potential negative side effects. To provide proper counseling of their patients, the diligent otolaryngologist should be aware of the current status of the literature and the hazards associated with prescribing PPIs. PPIs must be prescribed correctly in order to optimize outcomes and reduce risks and costs to the healthcare system. Overuse and misuse of PPIs, on the other hand, raises the risk of side effects. Because most gastric-acid-related illnesses necessitate long-term treatment, patients taking additional drugs in addition to a PPI are likely to experience clinically significant adverse drug interactions. Clinicians must only administer PPIs when they are proved to be required.
Read the paper
Related studies
- Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use
- Ivth brazilian consensus conference on helicobacter pylori infection
- A pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia
- S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – März 2023 – AWMF-Registernummer: 021–013
- Step-by-step management of refractory gastresophageal reflux disease
- Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.