Predictive value and clinical treatment guidance of uterine artery blood flow parameters for recurrent pregnancy loss
Abstract
Objective: This study investigates the relationship between uterine artery blood flow parameters and the number of miscarriages, etiology, treatment protocol, and pregnancy outcomes in patients with recurrent pregnancy loss (RPL).
Methods: A retrospective observational cohort analysis was conducted on data from patients with RPL and women with a normal pregnancy who visited Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine and the International Peace Maternity and Child Health Hospital between October 2017 and December 2024. The study observed various parameters of uterine artery blood flow, comparing differences in the number of miscarriages, etiology, treatment protocol, and pregnancy outcomes. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of blood flow parameters on pregnancy outcomes.
Results: The study included 652 patients with RPL and 432 pregnant women with normal pregnancy. First, with increasing gestational age, the uterine artery systolic/end-diastolic velocity (S/D), pulsatility index (PI), and blood flow resistance index (RI) showed a downward trend in normal pregnancy. Second, as the number of spontaneous miscarriages increased, the uterine artery blood flow S/D ratio and PI value gradually increased, while the peak systolic velocity (PSV) and RI values showed no significant correlation with the number of miscarriages. Third, in patients with RPL caused by immunological factors, the…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 652 participants or records.
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