Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1
Abstract
The research aims of this proposal are:
* Specific Aim 1: To test whether an increase in nitric oxide signaling can increase vasodilator responses in young Black individuals.
* Specific Aim 2: To test whether a decrease in endothelin-1 signaling can increase vasodilator responses in young Black individuals.
Conditions: Vascular Function, Racial Disparity.
Primary outcome: Flow-mediated Dilation; Reactive Hyperemia (Cuff Release); Muscle Hyperemia (Passive Leg Movement); Muscle Hyperemia (Rhythmic Handgrip Exercise); Muscle Hyperemia (Rhythmic Knee Extension Exercise).
Enrollment: 8 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 8 participants or records.
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