Mechanisms of Exercise Intolerance in Cystic Fibrosis: Role of PDE5 Inhibition
Abstract
Exercise intolerance is an understudied phenomenon in people with CF. The investigators hypothesized that vascular dysfunction plays a significant role, and can be partially reversed by administration of the phosphodiesterase type 5 (PDE5) inhibitor, sildenafil.
Conditions: Cystic Fibrosis.
Primary outcome: 6 Minute Walk Distance (6MWD).
Enrollment: 31 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 31 participants or records.
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