The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue
Abstract
This study is funded by the Moody Endowment. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on skeletal muscle anabolism, muscle strength, physical function, and body composition in older individuals. Further, we will determine whether augmentation of NO-mediated signaling reduces fatigue and fatigability.
Conditions: Fatigue.
Primary outcome: Skeletal Muscle Fatigue as Measured by Biodex 4 Pro After 4 Weeks of Placebo; Skeletal Muscle Fatigue as Measured by Biodex 4 Pro After 4 Weeks of Active Drug; Exercised Induced Fatigability as Measured by Fatigue Rating Scale After 4 Weeks of Placebo; Exercised Induced Fatigability as Measured by Fatigue Rating Scale After 4 Weeks of Active Drug.
Enrollment: 30 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 30 participants or records.
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